49029-2
LaboratoryCortisol Free/Cortisone free [Mass Ratio] in Urine
Definition
Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.
LOINC 6-Axis Classification
Component
Cortisol.free/Cortisone.free
Property
MRto
Time Aspect
Pt
System
Urine
Scale Type
Qn
Method Type
N/A
Details
Class
CHEM
Order/Observation
Both
Short Name
Cortis F/Cortisone Free Ur
Display Name
Cortisol Free/Cortisone free (U) [Mass ratio]
Related Names
Frequently Asked Questions
What is LOINC code 49029-2?
LOINC code 49029-2 identifies "Cortisol Free/Cortisone free [Mass Ratio] in Urine". Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.
What does 49029-2 measure?
This code measures Cortisol.free/Cortisone.free in Urine. It belongs to the CHEM class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.