49010-2
LaboratoryPlatelet aggregation [Units/volume] in Platelet rich plasma by ADP induced
Definition
Assay is used to measure platelet P2Y12 receptor blockade known to occur with some drugs including the thienopyridine class of drugs, including clopidogrel (Plavis(r)). VerifyNow P2Y12 Assay from Accumetrics uses adenosine-5-diphosphate(ADP/PGE1) to induce platelet activation. Activated platelets bind fibrinogen in proportion to the number of expressed platelet GPIIb/IIIa receptors. Light transmittance increases as activated platelets bind and aggregate the fibrinogen-coated beads. A turbidimetric based optical detection system measures change in optical signal caused by aggregation and reports results in P2Y12 Reaction Units(PRU). Information from VerifyNow P2Y12 Assay package insert from Accumetrics dated 2006 09 01
LOINC 6-Axis Classification
Component
Platelet aggregation
Property
ACnc
Time Aspect
Pt
System
PRP
Scale Type
Qn
Method Type
Aggregometry.adenosine diphosphate induced
Details
Class
COAG
Order/Observation
Both
Short Name
PA PRP ADP-aCnc
Display Name
Platelet aggregation Qn (PRP)
Related Names
Frequently Asked Questions
What is LOINC code 49010-2?
LOINC code 49010-2 identifies "Platelet aggregation [Units/volume] in Platelet rich plasma by ADP induced". Assay is used to measure platelet P2Y12 receptor blockade known to occur with some drugs including the thienopyridine class of drugs, including clopidogrel (Plavis(r)). VerifyNow P2Y12 Assay from Accumetrics uses adenosine-5-diphosphate(ADP/PGE1) to induce platelet activation. Activated platelets bind fibrinogen in proportion to the number of expressed platelet GPIIb/IIIa receptors. Light transmittance increases as activated platelets bind and aggregate the fibrinogen-coated beads. A turbidimetric based optical detection system measures change in optical signal caused by aggregation and reports results in P2Y12 Reaction Units(PRU). Information from VerifyNow P2Y12 Assay package insert from Accumetrics dated 2006 09 01
What does 49010-2 measure?
This code measures Platelet aggregation in PRP. It belongs to the COAG class in the LOINC classification.
What is LOINC?
LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.