14117-6

LOINC code 14117-6 identifies "IgG clearance/Albumin clearance [Ratio] in Serum and CSF". Ratio of a patient's IgG and albumin in CSF to the IgG and albumin in serum is of diagnostic value in a number of neurological disorders. Normally CSF albumin and IgG are derived from the serum, whereas in patients with active multiple sclerosis, the increased CSF IgG is believed to be synthesized within the CSF. The CSF Index is a calculated value which expresses the ratio of IgG to albumin in CSF, to the ratio of IgG to albumin in serum. An elevated ratio suggests local CNS synthesis of IgG. An increased CSF/IgG Index is found in diseases such as MS, neurosyphilis, subacute sclerosing panencephalitis (SSPE), chronic CNS infections and CNS lupus erythematosus.

This code measures IgG clearance/Albumin clearance in Ser+CSF. It belongs to the CHEM class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.