112301-7

LOINC code 112301-7 identifies "Leukocyte deformability sepsis assessment [Interpretation] in Blood by Microfluidic deformability cytometer". This term represents a test which measures biophysical and morphological changes in leukocytes (white blood cells) that occur during immune activation and dysregulation, with a specific focus on detecting sepsis. The test analyzes circulating neutrophils, monocytes, and other white blood cells using microfluidic technology to quantify cellular mechanical properties-particularly visco-elastic inertial response (VEIR): which reflects cell density, size, deformability, and viscosity. These biophysical properties change dramatically during leukocyte activation, including nuclear rearrangement and the early stages of neutrophil extracellular trap (NET) formation, processes characteristic of dysregulated immunity in sepsis. [PMID:37189536]

This code measures Leukocyte deformability sepsis assessment in Bld. It belongs to the CELLMARK class in the LOINC classification.

LOINC (Logical Observation Identifiers Names and Codes) is a universal standard for identifying laboratory and clinical observations. It is maintained by the Regenstrief Institute and used worldwide for health data exchange.