R65.21
BillableSevere sepsis with septic shock
Severe sepsis with septic shock
Coding Notes
Excludes 2
Conditions not included here, but the patient may have both
Code First
The underlying condition must be sequenced before this code
- underlying infection, such as:
- infection following a procedure (T81.4-)
- infections following infusion, transfusion and therapeutic injection (T80.2-)
- puerperal sepsis (O85)
- sepsis following complete or unspecified spontaneous abortion (O03.87)
- sepsis following ectopic and molar pregnancy (O08.82)
- sepsis following incomplete spontaneous abortion (O03.37)
- sepsis following (induced) termination of pregnancy (O04.87)
- sepsis NOS (A41.9)
Use Additional Code
Additional codes that should follow this code
- code to identify specific acute organ dysfunction, such as:
- acute kidney failure (N17.-)
- acute respiratory failure (J96.0-)
- critical illness myopathy (G72.81)
- critical illness polyneuropathy (G62.81)
- disseminated intravascular coagulopathy [DIC] (D65)
- encephalopathy (metabolic) (septic) (G93.41)
- hepatic failure (K72.0-)
Also Known As / Clinical Terms
SNOMED CT
- Failed attempted abortion with septic shock12983003
- Failed attempted termination of pregnancy with septic shock12983003
- Septic shock due to transfusion15765005
- Miscarriage with septic shock18613002
- Spontaneous abortion with septic shock18613002
- Miscarriage complicated by shock34270000
- Miscarriage with circulatory collapse34270000
- Spontaneous abortion complicated by shock34270000
- Spontaneous abortion with circulatory collapse34270000
- Failed attempted abortion complicated by shock67042008
- Failed attempted abortion with circulatory collapse67042008
- Failed attempted termination of pregnancy complicated by shock67042008
- Pyrogenic shock70993000
- Sepsis-associated hypotension76571007
- Septic shock76571007
- Septicaemic shock76571007
- Septicemic shock76571007
- Hyperdynamic septic shock234173007
- Hyperdynamic septicaemic shock234173007
- Hyperdynamic septicemic shock234173007
- Warm septic shock234173007
- Cold septic shock234174001
- Hypodynamic septic shock234174001
- Hypodynamic septicaemic shock234174001
- Hypodynamic septicemic shock234174001
- Endotoxicosis370515002
- Endotoxic shock371769008
- Gram-negative septic shock371769008
- Gram-negative shock371769008
- Endotoxaemia371770009
- Endotoxemia371770009
- Induced termination of pregnancy complicated by shock609453002
- Termination of pregnancy complicated by shock609453002
- Induced termination of pregnancy complicated by postoperative shock609479006
- Termination of pregnancy complicated by postoperative shock609479006
- Induced termination of pregnancy complicated by septic shock609487007
- Termination of pregnancy complicated by septic shock609487007
- Induced termination of pregnancy complicated by infectious disease609510000
- Septic shock following molar pregnancy1263928008
- Septic shock following ectopic pregnancy1263929000
- Shock following molar pregnancy1263943005
- Postprocedural septic shock12266551000119108
- Septic shock after procedure12266551000119108
- Sepsis caused by Chromobacterium1092571000119109
- Severe sepsis with acute organ dysfunction caused by Chromobacterium1092571000119109
- Septic shock co-occurrent with acute organ dysfunction caused by Haemophilus influenzae127171000119100
- Septic shock co-occurrent with acute organ dysfunction caused by Meningococcus127181000119102
- Septic shock co-occurrent with acute organ dysfunction caused by Pneumococcus127261000119100
- Septic shock co-occurrent with acute organ dysfunction caused by Pseudomonas127201000119101
- Septic shock co-occurrent with acute organ dysfunction caused by Serratia127231000119108
- Septic shock co-occurrent with acute organ dysfunction caused by Streptococcus127251000119102
- Septic shock co-occurrent with acute organ dysfunction caused by anaerobic bacteria127141000119107
- Septic shock co-occurrent with acute organ dysfunction caused by methicillin resistant Staphylococcus aureus128381000119104
- Septic shock co-occurrent with acute organ dysfunction caused by methicillin susceptible Staphylococcus aureus127191000119104
- Septic shock co-occurrent with acute organ dysfunction due to Chromobacterium1092471000119105
- Septic shock co-occurrent with acute organ dysfunction due to Enterococcus1092491000119106
- Septic shock co-occurrent with acute organ dysfunction due to Gonococcus1092501000119104
- Septic shock co-occurrent with acute organ dysfunction due to Gram-positive coccus1092511000119101
- Septic shock co-occurrent with acute organ dysfunction due to Group A streptococcus1092531000119106
- Septic shock co-occurrent with acute organ dysfunction due to Group B streptococcus1092541000119102
- Septic shock co-occurrent with acute organ dysfunction due to Staphylococcus127241000119104
- Septic shock co-occurrent with acute organ dysfunction due to coagulase-negative Staphylococcus1092481000119108
- Shock due to ectopic pregnancy10751391000119109
Frequently Asked Questions
What is the ICD-10 code for severe sepsis with septic shock?
The ICD-10-CM code for severe sepsis with septic shock is R65.21. The full clinical description is "Severe sepsis with septic shock". R65.21 is a billable/specific code that can be used on insurance claims and medical billing.
What does ICD-10 code R65.21 mean?
ICD-10-CM code R65.21 represents "Severe sepsis with septic shock". It is classified under Chapter 18: Symptoms, Signs and Abnormal Clinical and Laboratory Findings and is a billable/specific code that can be used on a claim.
Is R65.21 a billable code?
Yes, R65.21 is a billable/specific ICD-10-CM code and can be used to indicate a diagnosis on a medical claim.
What chapter is R65.21 in?
R65.21 is in Chapter 18: Symptoms, Signs and Abnormal Clinical and Laboratory Findings (codes R00-R99).
Are additional codes required with R65.21?
Yes, when using R65.21 you should also code: code to identify specific acute organ dysfunction, such as:; acute kidney failure (N17.-); acute respiratory failure (J96.0-); critical illness myopathy (G72.81); critical illness polyneuropathy (G62.81); disseminated intravascular coagulopathy [DIC] (D65); encephalopathy (metabolic) (septic) (G93.41); hepatic failure (K72.0-).
What SNOMED CT codes does R65.21 map to?
R65.21 maps to 39 SNOMED CT concepts: 234174001, 371770009, 371769008, 370515002, 67042008, and 34 more. SNOMED CT is a clinical terminology used in electronic health records.
What are the UMLS CUIs for R65.21?
R65.21 is linked to 1 UMLS Concept Unique Identifier: C2830470. The UMLS (Unified Medical Language System) integrates multiple biomedical vocabularies maintained by the U.S. National Library of Medicine.
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Includes SNOMED Clinical Terms® (SNOMED CT®) used by permission of SNOMED International. Includes content from the UMLS Metathesaurus, courtesy of the U.S. National Library of Medicine.